Bone disease in primary hyperparathyroidism

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Bone disease in primary hyperparathyroidism.

The classic bone disease of primary hyperparathyroidism, osteitis fibrosa cystica, was characterized by subperiosteal bone resorption, osteopenia, and "brown tumors." Since the description of this skeletal disorder, the clinical profile of primary hyperparathyroidism has evolved markedly. The disease today is often characterized by no more than asymptomatic hypercalcemia, and severe bone diseas...

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Primary Hyperparathyroidism: A Report on 30 Cases of the Disease

Primary hyperparathyroidism is not nowadays considered a rare disease and according to some reports, its incidence is 1/1000. This disorder can be accompanied with severe complications including renal failure and bone illnesses and this can highly elevate the treatment costs and causes social problems and troubles within families. The descriptive strategy of this study was carried out on 30 pa...

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Most patients with primary hyperparathyroidism are women in their postmenopausal years. The serum calcium concentration is typically within 1 mg/dL above the upper limit of normal, and the parathyroid hormone concentration is usually 1.5 times above the upper limit of normal. Hypercalciuria is seen in approximately 40% of patients. Hypophosphatemia, reflecting the physiologic actions of PTH to ...

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Primary hyperparathyroidism: pathophysiology and impact on bone.

Primary hyperparathyroidism has been associated with bone loss, especially at cortical skeletal sites. Results from studies evaluating the mineral density of cancellous bone have been more difficult to interpret. Most densitometry studies support the concept that the parathyroid hormone appears to be catabolic at cortical sites and may have anabolic effects at cancellous bone sites. Studies com...

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Chondrocalcinosis in primary hyperparathyroidism. Influence of age, metabolic bone disease, and parathyroidectomy.

Chondrocalcinosis is known to be common in hyperparathyroidism. In order to discover the effect of parathyroidectomy on chondrocalcinosis and to investigate this association further, we studied two groups of patients. In one group were 41 postparathyroidectomy patients, and in the other 100 admissions to the acute geriatric unit. The total incidence of chondrocalcinosis in the parathyroidectom...

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ژورنال

عنوان ژورنال: Arquivos Brasileiros de Endocrinologia & Metabologia

سال: 2014

ISSN: 0004-2730

DOI: 10.1590/0004-2730000003381